replication stress造句

• Replication stress is observed in preneoplastic cells due to increased proliferation signals from oncogenic mutations.
• The formation of single-stranded DNA occurs frequently, more often during replication stress.
• Apoptosis might drive genomic instability by facilitating the emergence of pathologic clones during phases of proliferation and subsequent replication stress-associated DNA damage.
• Replication stress is characterized by : increased replication initiation / origin firing; increased transcription and collisions of transcription-replication complexes; nucleotide deficiency; increase in reactive oxygen species ( ROS ).